Goshen Lab

Refaeli R, Kreisel T, Ravins-Yaish T, Groysman M, Goshen I. (2024). Astrocytes Control Recent and Remote Memory Strength by Affecting the Recruitment of the CA1àACC Projection to Engrams. Cell Reports. 43(3):113943

Refaeli R, Kreisel T, Goshen I. (2024). Analyzing Engram Reactivation and Long-Range Connectivity. STAR Protocols. 5(1):102840

Refaeli R, Kreisel T, Groysman M, Adamsky A, Goshen I. (2023).

Engram Stability and Maturation During Systems Consolidation.

Current Biology

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Current Biology: Rashid AJ, Golbabaei A, Josselyn SA. (2023). Memory: Meet the new engram, same as the old engram. 33(18):R955-R957.

Doron A, Rubin A, Benmelech-Chovav A, Benaim N, Carmi T, Refaeli R, Novick N, Kreisel T, Ziv Y, Goshen I.

Hippocampal Astrocytes Encode Reward Location.

Nature

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Nat Rev Neurosci: Lewis S, (2022). Rewarding astrocytes. 23(11):645.

Goshen I, Yirmiya R, Kol A.

Mentoring: a three-generation perspective.

Neuron

Refaeli R, Goshen I.

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains.

J Vis Exp.

Refaeli R*, Doron A*, Benmelech-Chovav A, Groysman M, Kreisel T, Loewenstein Y, Goshen I.

Features of Hippocampal Astrocytic Domains and their Spatial Relation to Excitatory and Inhibitory Neurons.

Glia

Goshen I.  Q&A. Neuron.

2021

Kol A, Adamsky A, Groysman M, Kreisel T, London M, Goshen I.

Astrocytes Contribute to Remote Memory Formation by Modulating Hippocampal-Cortical Communication During Learning.

Nature Neuroscience.

Kol A and Goshen I.

The memory orchestra: the role of astrocytes and oligodedrocytes in parallel to neurons.

Current Opin. in Neurobiol.

Doron A, Goshen I. (2020) Glia: The glue holding memories together. Neuron

Hirbec H, Deglon N, Foo LC, Goshen I, Grutzendler J, Hangen E, Kreisel T, Linck N, Muffat J, Regio S, Rion S, Escartin C. Emerging technologies to study glial cells. Glia, 2020

Adamsky A*, Kol A*, Kreisel T, Doron A, Ozeri-Engelhard N, Melcer T, Refaeli R, Horn H, Regev L, Groysman M, London M, Goshen I.

Astrocytic activation generates de novo neuronal potentiation and memory enhancement.

Cell

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Cell: Covelo A, Araque A. (2018). Stimulating astrocytes to remember. 174(1):12-13

Faculty of 1000: Sala, C (2018). Rated "Exceptional". F1000Prime.com/733283387 #eval793548051.​

Doron A, Goshen I. (2018) Investigating the transition from recent to remote memory using advanced tools. Brain Res Bull.

Atlan G, Terem A, Peretz-Rivlin N, Sehrawat K, Gonzales BJ, Pozner G, Tasaka GI, Goll Y, Refaeli R, Zviran O, Lim BK, Groysman M, Goshen I, Mizrahi A, Nelken I, Citri A. (2018) The Claustrum Supports Resilience to Distraction. Current Biology

Adamsky A, Goshen I. (2018). Astrocytes in memory function: Pioneering findings and future directions. Neuroscience.

Milshtein-Parush H, Frere S, Regev L, Lahav C, Benbenishty A, Ben-Eliyahu S, Goshen I, Slutsky I. (2017) Sensory Deprivation Triggers Synaptic and Intrinsic Plasticity in the Hippocampus. Cerebral Cortex.

Daadi MM, Klausner JQ, Bajar B, Goshen I, Lee-Messer C, Lee SY, Winge MC, Ramakrishnan C, Lo M, Sun G, Deisseroth K, Steinberg GK. (2016). Optogenetic Stimulation of Neural Grafts Enhances Neurotransmission and Downregulates the Inflammatory Response in Experimental Stroke Model. Cell Transplant. 25(7):1371-80

Goshen I. (2014). The optogenetic revolution in memory research. Trends in neurosciences 37(9):511-22

Prakash R. Yizhar O, Grewe B, Ramakrishnan C, Wang N, Goshen I, Packer AM, Peterka DS, Yuste R, Schnitzer MJ, Deisseroth K. (2012). Two-photon optogenetic toolbox for fast inhibition, excitation, and bistable modulation. Nature Methods 9(12):1171-9.

Goshen I, Brodsky M, Prakash R, Wallace J, Gradinaru V, Ramakrishnan C, Deisseroth K. (2011). Dynamic retrieval strategies for remote memories. Cell 147(3):678-89.

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Highlighted in:

Cell: Suzuki W, Naya Y. (2011). Two routes for remembering the past. 147(3):493-5.

Nat Rev Neurosci: Welberg L, (2001). Learning and memory: CA1 triggers the trace. 12(12):705.

Trends Cogn Sci: McKenzie S, Eichenbaum H (2012). New approach illuminates how memory systems switch. 16(2):102-3.

Faculty of 1000: Four reviews: Giocomo L, Moser E (2011) rated "Exceptional", Hawk J, Abel T (2011) rated "Must Read", Sahay A (2012) rated "Exceptional", Holzman D and Bero A (2012) rated "Exceptional". F1000.com/13357417.

Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K. (2011). Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477(7363):171-8.

Licht T*, Gishen I*, Avital A, Kreisel T, Zubedat S, Eavri R, Segal M, Yirmiya R, Keshet E. (2011). Reversible modulations of neuronal plasticity by VEGF. Proc Natl Acad Sci U S A 108(12):5081-6.

Yirmiya R, Goshen I. (2011). Immune modulation of memory functioning, neural plasticity and neurogenesis. Brain, Behavior and Immunity, 25(2):181-213.

Anikeeva P, Andalman AS, Witten IB, Warden MR, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K. (2011). Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nature Neuroscience. 15(1):163-70.

Ben Menachem-Zidon O, Avital A, Ben-Menachem Y, Goshen I, Kreisel T, Shmueli EM, Segal M, Ben Hur T, Yirmiya R. (2011). Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling. Brain, Behavior and Immunity 25(5):1008-16.

Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim DS, Fenno LE, Ramakrishnan C, Deisseroth K. (2010). Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature 465(7299):788-92.

Gradinaru V, Zhang F, Ramakrishnan C, Mattis J, Prakash R, Diester I, Goshen I, Thompson KR, Deisseroth K. (2010). Molecular and cellular approaches for diversifying and extending optogenetics. Cell 141(1):154-65.

Licht T, Eavri R, Goshen I, Shlomai Y, Mizrahi A, Keshet E. (2010). VEGF is required for dendritogenesis of newly-born olfactory bulb inter-neurons. Development 137(2):261-71.

Goshen I, Avital A, Kreisel T, Licht T, Segal M, Yirmiya R. (2009). Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement. J Neuroscience 29(11):3395-403.

Goshen I, Yirmiya R (2009). Interleukin-1 (IL-1): a central regulator of stress responses. Front Neuroendocrinal 30(1):30-45.

Ounallah-Saad H, Beeri R, Goshen I, Yirmiya R, Renbaum P, Levy-Lahad E, (2009). Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue. Gene 446(2):81-89.

Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, and Yirmiya R. (2008). Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Molecular Psychiatry 13(7):717-28

Ben-Menachem-Zidon O, Goshen I, Kreisel T, Ben-Menachem Y, Reinhartz E, Ben Hur T, Yirmiya R. (2008). Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacology 33(9):2251-62.

Goshen I, Kreisel T, Ounallah-Saad H, Renbaum P, Zalzstein Y, Ben-Hur T, Levy-Lahad E, Yirmiya R. (2007). A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology 32(8-10):1106-15.

Wolf G, Yirmiya R, Kreisel T, Goshen I, Weidenfeld J, Poole S, Shavit Y. (2007). Interleukin-1 signaling modulates stress-induced analgesia. Brain, Behavior and Immunity 21(5):652-9.

Yirmiya R, Goshen I, Bajayo A, Kreisel T, Feldman S, Tam J, Tremblover V, Csernus V, Shohami E, Bab I. (2006). Depression induces bone loss through stimulation of the sympathetic nervous system. Proc Natl Acad Sci U S A. 103(45):16876-81.

Bajayo A*, Goshen I*, Feldman S, Csernus V, Iverfelt K, Shohami E, Yirmiya R, Bab I. (2005). Central IL-1 receptor signaling regulates bone growth and mass. Proc Natl Acad Sci USA. 102(36):12956-12961.

Shavit Y, Wolf G, Goshen I, Livshits D, Yirmiya R. (2005). Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance. Pain 115(1-2):50-59.

Weidenfeld J, Itzhik A, Goshen I, Yirmiya R, Ben-Hur T. (2005). Role of the central amygdala in modulating the pituitary-adrenocortical and clinical responses in experimental herpes simplex virus-1 encephalitis. Neuroendocrinology. 81(4): 267-272.

Goshen I, Yirmiya R, Iverfeldt K, Weidenfeld J. (2003). The role of Interleukin-1 (IL-1) in HPA axis regulation following stress and adrenalectomy.

Endocrinology, 144(10):4453-4458.

Avital A*, Goshen I*, Kamsler A*, Segal M, Iverfelt K, Richter-Levin G, Yirmiya R. (2003). Impaired interleukin-1 (IL-1) signaling is associated with defects in memory processes and neural plasticity. Hippocampus. 13:826-834.

Wolf G, Yirmiya R, Goshen I, Iverfeldt K, Holmlund L, Takeda K, Shavit Y. (2003). Impairment of Interleukin-1 (IL-1) signaling reduces baseline pain sensitivity in mice: genetic, pharmacological and developmental aspects. Pain 104:471-480.  

Yirmiya R, Winocur G, Goshen I. (2002). Brain interleukin-1 is involved in spatial memory and passive avoidance conditioning. Neurobiology of learning and memory, 78:379-389.  

Barak O, Goshen I, Ben-Hur T, Weidenfeld J, Taylor AN, Yirmiya R. (2002). Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120. Brain Research, 933:98-108. 

Pollak Y, Orion E, Goshen I, Ovadia H, Yirmiya R. (2002) Experimental

autoimmune encephalomyelitis-associated behavioral syndrome as a model of ‘depression due to multiple sclerosis’. Brain, Behavior and Immunity, 16:533-543.  

Barak O, Weidenfeld J, Goshen I, Ben-Hur T, Taylor AN, Yirmiya R. (2002). Intracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary-adrenal activation in rats: role of prostaglandins. Brain, Behavior and Immunity, 16:720-735.  

Pollak Y, Ovadia H, Goshen I, Gurevich R, Monsa K, Avitsur R, Yirmiya R. (2000). Behavioral aspects of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 104:31-36.